profoundly
adv. 极大地，深刻地；严重地，完全地
例句
We are profoundly affected by what happens to us in childhood.
童年发生的事深深地影响着我们。
《牛津词典》
She is now profoundly deaf.
她现在几乎一点声音都听不到了。
《柯林斯英汉双解大词典》
This has profoundly affected my life.
这已极大地影响了我的生活。
