英语语法分析

Objective:To observe the safety and efficacy of topical tacalcitol ointment in the treatment of palmoplantar pustulosis.

目的：观察他卡西醇软膏外用治疗掌跖脓疱病的疗效及安全性。

The main manifestation was hypopigment, hyperpigment, and palmoplantar Hyperkeratosis. Triad cases happened in 72 patients (7.35%).

主要表现为色素脱失、色素沉着及掌跖过度角化，具此三联症者72例（7．35％）。

Conclusion the mutation G485A found in keratin 9 gene is the disease-causing mutation in the diffuse palmoplantar keratoderma family.

结论：角蛋白9基因的G485A突变是导致该家系发生弥漫性掌跖角化病的原因。